对于运动障碍的清醒与睡眠深度大脑刺激后的30天的短期不良事件:全国性的基于注册的研究
Victor Gabriel El-Hajj1, Ryan Nguyen2, Abdul Karim Ghaith3
1Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Brain & spine
|September 2, 2025
概括
睡眠和清醒的深度大脑刺激 (DBS) 对帕金森病和基本患者的短期结果相似. 这表明麻醉选择可以个性化,优先考虑患者的需求和最佳DBS治疗的偏好.
科学领域:
- 神经外科
- 麻醉学
- 神经学
背景情况:
- 深度脑刺激 (DBS) 是治疗耐火运动障碍和的关键疗法.
- 麻醉方式 (睡觉或清醒) 是DBS程序的关键考虑因素.
- 以患者为中心的护理需要了解不同DBS麻醉方法的比较安全性和有效性.
研究的目的:
- 为了比较睡眠和清醒的深度脑刺激 (DBS) 的不良事件率.
- 根据DBS程序的麻醉选择,以患者为中心的决策.
- 评估睡眠与清醒DBS相关的短期结果.
主要方法:
- 对ACS国家外科质量改进计划 (NSQIP) 数据库 (2011-2020) 的分析.
- 包括被诊断患有帕金森病或基本震的DBS患者.
- 应用2:1倾向分数匹配来比较睡眠和清醒的DBS组的结果.
主要成果:
- 分析了1778名患者 (75. 7%在睡眠状态, 24. 3%在清醒状态).
- 两组之间没有观察到基线差异.
- 在睡眠和清醒DBS之间发现了可比的30天并发症率 (2.3%睡觉 vs 0.7%清醒; p=0.062),再入院,重手术和非家庭出院.
结论:
- 在对应的分析中,睡眠和清醒的DBS显示了可比的30天结果.
- 在并发症,再入院,重复手术或住院期间没有发现显著差异.
- 这些发现支持临床平衡,强调基于患者因素的个人化麻醉选择.
相关概念视频
Stages of Sleep
Sleep progresses through distinct stages, each characterized by specific brain wave patterns and physiological responses ranging from wakefulness to stages of non-rapid eye movement, known as non-REM, to rapid eye movement, referred to as REM. Understanding these stages helps in recognizing how sleep supports various bodily and cognitive functions.
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
REM Sleep Behavior Disorder
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
RBD is significantly associated with...
Substance Use Disorders Affecting Sleep
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...


