在手术前的血清脂质作为同时发生的甲状腺癌的新预测因子
Xingxing Gao1, Mi Liu2, Yijun Wu1
1Department of Thyroid Surgery, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
PeerJ
|September 2, 2025
概括
高水平的甘油三和低水平的HDL胆固醇是发生甲状腺癌的危险因素. 超重状态也会增加恶性瘤的风险,这表明脂质样本可以预测GD患者的甲状腺癌.
科学领域:
- 内分泌学
- 癌症学
- 代谢研究
背景情况:
- 格雷夫斯病 (GD) 越来越多地与甲状腺癌有关.
- 甲状腺癌患者的脂质概况与甲状腺癌发病率之间的联系尚不清楚.
研究的目的:
- 在患有格雷夫斯病的患者中研究血清脂度与甲状腺癌的发生之间的联系.
- 确定甲状腺恶性瘤的预测因素.
主要方法:
- 对512名接受手术的格雷夫斯病患者的回顾性分析 (2015-2024年).
- 用物流回归模型识别甲状腺癌的危险因素.
- 开发和验证甲状腺癌风险的预测名录.
主要成果:
- 分化甲状腺癌 (DTC) 在58. 4%的患者中得到证实.
- 高甘油 (TAG),低高密度脂蛋白 (HDL) 和超重 (BMI ≥25) 是恶性瘤的重要危险因素.
- 在训练和验证组中,预测性名录显示出高准确度 (AUC 0. 91).
- 高TAG水平与淋巴结转移和晚期AJCC发生相关.
结论:
- 提升的TAG,降低的HDL和超重状态独立地与GD患者的甲状腺癌发病率有关.
- 在此群体中,手术前的脂质概况和BMI可以作为甲状腺癌的有价值预测指标.
相关概念视频
Blood Studies for Cardiovascular System III: Serum Lipid Profile
291
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
291
Synthesis and Regulation of Thyroid Hormones
5.1K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
5.1K
The Thyroid Gland
4.3K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
4.3K
Lipids: Dietary Sources and Requirements
1.0K
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
1.0K


