意大利的症状 (STB) 和无症状 (ATB) 结核病:多中心回顾性研究的结果
Sergio Cotugno1, Giacomo Guido1, Francesco Di Gennaro1
1Clinic of Infectious Diseases, Department of Precision and Regenerative Medicine and Jonian Area (DiMePreJ), Bari, Italy.
Journal of clinical tuberculosis and other mycobacterial diseases
|September 2, 2025
概括
与无症状结核病例相比,症状结核病 (STB) 的病例表现出更多不良事件和更长的住院时间. 由于其无声的性质,ATB在消除结核病方面存在挑战.
科学领域:
- 传染性疾病
- 肺病学
- 临床医学
背景情况:
- 无症状结核病 (ATB) 占结核病总病例的很大一部分.
- 区分ATB和症状性结核病 (STB) 对于了解疾病负担和优化治疗策略至关重要.
研究的目的:
- 为了比较ATB和STB患者的人口和临床特征.
- 评估ATB和STB之间的不良事件,住院时间和治疗结果的差异.
主要方法:
- 一项多中心的回顾性研究,涉及510名经微生物学确认的肺结核患者.
- 在2018年至2023年间从10家意大利医院收集的数据.
- 患者被分为ATB (没有症状) 或STB (咳,发烧,胸痛等). ) 的情况.
主要成果:
- 在研究的结核病例中,ATB占36. 4%.
- 性病例与糖尿病,乙型肝炎和结核病史有关.
- 与ATB患者相比,STB患者的不良事件发生率和严重程度显著增加,住院时间长达24%.
结论:
- 有症状的结核病与不良反应和长时间住院的负担有关.
- 无症状的ATB为有效的结核消除工作带来了独特的挑战.
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