肌缩侧面硬化和常见癌症的风险:孟德尔随机化因果关系和调解的质疑
Xiaoxue Tan1,2, Gaifen Liu3,4, Xiangnan Li2
1Center for Medical Research and Innovation, Shanghai Pudong Hospital and Pudong Medical Center, Shanghai Medical College, Fudan University, Shanghai, 200120 China.
Phenomics (Cham, Switzerland)
|September 2, 2025
概括
肌缩侧面硬化症 (ALS) 可能导致结肠直肠癌 (CRC) 的风险降低. 这项遗传研究没有发现与其他癌症的关联,这表明ALS和CRC之间存在特定的反向关系.
科学领域:
- 神经科学
- 癌症学
- 遗传学
背景情况:
- 神经退行性疾病和癌症之间的反向共患性已被记录,但与肌缩侧面硬化症 (ALS) 的关联仍然不清楚.
- 了解ALS和癌症之间的病因关系对于疾病预防和治疗策略至关重要.
研究的目的:
- 研究ALS与包括结直肠癌 (CRC) 在内的各种癌症之间的潜在因果关系.
- 探索血清脂质特征的调解作用,如高脂血症,在ALS和CRC之间的关联.
主要方法:
- 使用孟德尔随机化 (MR) 分析与全基因组关联研究 (GWAS) 的总结统计数据,用于ALS和九种常见的固体癌症.
- 使用反变量加权 (IVW) 方法和补充灵敏度分析,包括MR-Egger,MR-PRESSO和Cochran的Q测试.
- 进行了基于MR的调解分析,以评估超脂血症在ALS-CRC相关性的作用.
主要成果:
- 在欧洲和东亚人群中,基因预测ALS与CRC风险降低有关.
- 在ALS和整体癌症或其他特定癌症类型之间没有发现显著的因果关系.
- 调解分析表明,高脂血症可能通过ALS间接影响CRC风险.
结论:
- 基因代理ALS可能与CRC风险降低有因果关系,为神经退行性疾病与癌症的相互作用提供了新的见解.
- 这些发现有助于理解神经退行性疾病和癌症之间的逆并发症和病因关系.
更多相关视频
09:38Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
15.1K
05:51A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
Published on: June 15, 2011
26.0K
相关概念视频
02:59Cancer Prevention
6.3K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.3K
01:20Mismatch Repair
5.2K
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
5.2K
02:21Cancers Originate from Somatic Mutations in a Single Cell
12.7K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
12.7K
01:03Rous Sarcoma Virus (RSV) and Cancer
5.4K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.4K
02:41Lethal Alleles
15.7K
Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
15.7K
01:25Mutagenicity and Carcinogenicity
1.4K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.4K