与全身性塔克罗利木斯相关的亚托皮炎:病例报告和综述
Sheenagh J K Luijk1, Cathryn J Sibbald1
1Division of Dermatology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, ON, Canada.
SAGE open medical case reports
|September 2, 2025
概括
在移植患者中,系统性塔克罗利莫斯可能会诱发亚托皮炎 (AD). 在接受肝移植的儿科患者中,将免疫抑制转换为西罗和单次杜皮卢马布剂量可以缓解阿尔茨海默病.
科学领域:
- 免疫学
- 皮肤病学
- 移植
背景情况:
- 移植后的免疫抑制对于移植的生存至关重要.
- 在器官移植后使用的常见免疫抑制剂.
- 无菌性皮肤炎 (AD) 是一种慢性炎症性皮肤疾病.
研究的目的:
- 在接受肝移植的儿童中报告新发性亚托皮炎病例.
- 调查系统性塔克罗利木斯在诱导亚托皮性皮肤炎中的潜在作用.
- 评估转换免疫抑制和向疗法的有效性,以控制塔克罗利斯诱导的AD.
主要方法:
- 一个10个月大的女肝移植患者的病例报告.
- 对移植后新发性湿疹的临床评估.
- 治疗包括从塔克罗利木斯转换为西罗利木斯,并给予一剂杜皮卢马布.
- 监测皮肤状况和治疗反应.
主要成果:
- 在肝移植后110天,患者在单一治疗中出现了新发性亚托皮炎 (AD).
- 传统的阿尔茨海默病治疗没有效果.
- 将免疫抑制药物从塔克罗利木斯转换为西罗利木斯和单一剂量杜皮卢马布,导致皮肤在一个月内显著改善.
- 在最后一次随访时,完全消失.
结论:
- 在儿童肝移植患者中,系统性塔克罗利莫斯可能会诱发或加重亚托皮炎.
- 将免疫抑制疗法从塔克罗利木斯转换为西罗利木斯可能是一个有效的策略.
- 杜皮卢马布可能是治疗严重病例的选择.
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