通过导管更换大动脉的患者的神经认知的前性评估
Srinivasa P Potluri1, Cody W Dorton2, Kyle A McCullough2
1Department of Cardiology, Baylor Scott & White The Heart Hospital, Plano, Texas, USA.
Structural heart : the journal of the Heart Team
|September 2, 2025
概括
在治疗后6个月内,透过导管的动脉置换 (TAVR) 显著改善了轻度认知障碍 (MCI) 的患者的神经认知功能. 在MCI患者中,TAVR是一种安全的选择.
科学领域:
- 心脏病学
- 神经学
- 老年病学
背景情况:
- 通过导管进行大动脉置换 (TAVR) 后的神经认知变化存在相互矛盾的数据.
- 这项研究主要针对接受TAVR的轻度认知障碍患者.
- 在TAVR后6个月内调查认知变化至关重要.
研究的目的:
- 在经过导管大动脉置换 (TAVR) 后长达6个月的轻度认知障碍 (MCI) 患者中研究神经认知功能变化.
主要方法:
- 前性,观察性,非随机的队列研究.
- 包括患有MCI的TAVR患者 (Mini- Montreal认知评估[Mini MoCA]得分≤25/ 30).
- 在TAVR前,在TAVR后30天和6个月评估Mini MoCA.
主要成果:
- 在TAVR后的30天 (p < 0. 001) 和6个月 (p < 0. 001) 中,Mini MoCA得分显著增加.
- 在30天后64. 4%和6个月后89. 4%的患者的认知能力得到改善.
- 与基线相比,6个月后Mini MoCA得分平均增加了2. 3个点.
结论:
- 透过导管的大动脉置换 (TAVR) 导致在基线轻度认知障碍 (MCI) 患者中显著的神经认知改善.
- 小蒙特利尔认知评估 (Mini MoCA) 有效地测量这些认知变化.
- 对于患有大动脉疾病和MCI的患者来说,TAVR是一种安全有效的治疗选择.
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