2型糖尿病患者甲状腺功能和维生素D水平的相关性分析
Lizhen Wu1, Bo Liang1, Ruhai Lin1
1Department of Endocrinology and Metabolism, the Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
Frontiers in endocrinology
|September 2, 2025
概括
维生素D缺乏与2型糖尿病患者的甲状腺问题有关. 对于患有甲状腺疾病的糖尿病患者,建议对维生素D缺乏进行查.
科学领域:
- 内分泌学
- 代谢疾病
- 营养科学
背景情况:
- 研究2型糖尿病 (T2DM) 的成年人维生素D状况与甲状腺功能之间的联系.
- 从2018年到2024年在第三级医院治疗的1805名T2DM患者.
- 分析人口,代谢和甲状腺的参数,以了解维生素D对甲状腺功能障碍的影响.
研究的目的:
- 在T2DM患者中确定维生素D水平与甲状腺功能之间的关联.
- 探索维生素D在甲状腺失调中的作用.
- 为潜在的查指南提供证据.
主要方法:
- 使用电化学发光测量了血25-维生素D,甲状腺激素 (FT3,FT4,TSH) 和自身抗体 (TPOAb,TGAb,TRAb).
- 通过HPLC评估HbA1c
- 使用斯皮尔曼相关性和逻辑回归来分析维生素D状态 (缺乏,不足,充足) 和甲状腺疾病之间的关系.
主要成果:
- 维生素D的充足与男性性别,年龄和高FT3相关,但与高甘油和HbA1c相反相关.
- 甲状腺功能过高与维生素D不足和年轻的年龄相关.
- 甲状腺功能低下与衰老和高胆固醇有关;维生素D与甲状腺自身免疫之间没有发现联系.
结论:
- 在T2DM患者中,维生素D缺乏与甲状腺功能障碍和亚临床甲状腺功能障碍独立相关.
- 表明维生素D在2型糖尿病患者的甲状腺失调中可能起作用.
- 支持对患有甲状腺功能障碍的糖尿病患者进行维生素D缺乏症查.
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