一个完全可植入的传感器化人工膀,以恢复尿和充满性监测
F Semproni1, V Iacovacci1, S Musco2
1The BioRobotics Institute and Department of Excellence in Robotics & AI, Scuola Superiore Sant'Anna, Pisa, Italy.
APL bioengineering
|September 2, 2025
概括
研究人员开发了一种软自敏感的人造膀 (S3AB),以改善急性囊切除术后的患者的生活质量. 这种可植入的装置恢复了膀满度的监测,使自然排泄管理成为可能.
科学领域:
- 生物医学工程
- 复原医学
- 泌尿外科
背景情况:
- 根性囊切除需要更换膀,如尿液转移或组织新膀具有限制.
- 现有的解决方案无法恢复膀充满的感觉,使排尿的自我管理复杂化.
- 需要一个完全可植入的,有传感器的器官来解决这些功能缺陷.
研究的目的:
- 介绍软自敏人工膀 (S3AB), 这是一种可植入的新型装置,
- 恢复尿液收集和膀充满的关键感觉,以改善患者的治疗.
- 在大型动物模型中评估S3AB的疗效.
主要方法:
- 开发一种,灵感来自于原木的人工膀,用于腹腔和腹腔内压力.
- 集成多传感器系统,使用耐用,稳定的电阻性织传感器进行体积监测.
- 通过重复填充/排水周期和植入大型动物模型来测试传感器的准确性和系统功能.
主要成果:
- 在填充和排水周期中,S3AB在生理温度下表现稳定.
- 通过内部体积监测,通过利用原形结构的扩张,实现了约12%的估计准确度.
- 在大型动物模型中,该设备成功恢复了尿液收集和填充状态的监测.
结论:
- 软自敏人工膀 (S3AB) 显示为需要膀置换的患者的可完全植入的解决方案.
- 集成的传感器系统有效监测膀体积,使自然排尿管理和改善患者的生活质量.
- 在大型动物模型中成功的临床前评估支持进一步的临床应用.
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