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研究领域生物医学和临床科学瘤学和致癌症预测和预后标志物
与癌症相关的PDPN+纤维细胞与胃癌的新辅助免疫疗法反应相关

与癌症相关的PDPN+纤维细胞与胃癌的新辅助免疫疗法反应相关

Mi Jian ¹, Zhensong Yang ¹, Yutao Tang ¹, Fangjie Jiang ², Li Cai ³, Aina Liu ⁴, Jinchen Hu ¹, Xixun Wang ¹, Shuguang Liu ¹, Dawei Zhao ¹, Miaomiao Li ¹, Hongbing Chen ¹, Menglai Zhang ¹, Zengwu Yao ¹, Rongbao Jia ¹, Ruyue Chen ⁵, Lixin Jiang ⁶, Yifei Zhang ¹, Xicheng Song ⁷

Mi Jian ¹, Zhensong Yang ¹, Yutao Tang ¹

¹Department of Gastrointestinal Surgery, Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University, Yantai 264000, Shandong, China.
²Department of Endocrinology, Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University, Yantai 264000, Shandong, China.
³Department of Pathology, Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University, Yantai 264000, Shandong, China.
⁴Department of Oncology, Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University, Yantai 264000, Shandong, China.
⁵Medical College, Qingdao University, Qingdao 266000, Shandong, China.
⁶Department of Surgical Department, The Yeda Hospital of Yantai City, Yantai 265500, Shandong, China.
⁷Department of Otorhinolaryngology-Head and Neck Surgery, Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University, Yantai 264000, Shandong, China.

⁰Department of Gastrointestinal Surgery, Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University, Yantai 264000, Shandong, China.

Apl Bioengineering +

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2025年九月2日

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在PubMed上查看摘要

概括

此摘要是机器生成的。

与癌症相关的纤维细胞 (CAF) 影响胃癌 (GC) 的免疫治疗反应. PDPN+ CAFs阻碍免疫反应,表明它们可以预测GC患者的治疗有效性.

科学领域

癌症学
免疫疗法
癌症生物学

背景情况

新辅助治疗后的病理完整反应 (pCR) 改善了胃癌 (GC) 的预后.
在免疫治疗后,GC组织的pCR表现为肌体刚性和纤维细胞增殖的增加.
癌症相关纤维细胞 (CAF) 被认为是免疫疗法的潜在生物标志物.

研究的目的

确定与CAF相关的基因作为GC免疫疗法的预测因子.
研究特定CAF亚群在GC对免疫疗法的反应中的作用.
评估波多普拉宁 (PDPN) 作为预测GC免疫治疗结果的潜在生物标志物.

主要方法

对TCGA-STAD,PRJEB25780,GSE27342和GSE54129数据库进行CAF相关基因的生物信息分析.
对GSE163558,GSE183904和GSE184198数据集进行单细胞RNA测序 (scRNA-seq) 分析.
使用GC患者衍生器官 (GC-PDO) 和免疫组织化学/免疫光学进行验证.

主要成果

确定PDPN是与免疫疗法的CAF相关标志物.
在实现pCR的GC样本中观察到较低的PDPN表达.
在抗PD-1 治疗中,PDPN+ CAF与pCR呈负相关性 (p < 0. 01).
发现PDPN+ CAF阻碍了免疫细胞的激活,并降低了GC的抗瘤免疫反应.

结论

在GC中,PDPN+ CAF可以作为免疫治疗反应的预测生物标志物.
向PDPN+CAF可能会提高胃癌患者的免疫疗效.
这项研究强调了特定CAF亚群在调节瘤免疫微环境和治疗结果方面的关键作用.

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相关概念视频

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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