亚拉克基过量不是一种敏感或特定的诊断工具,用于结肠的马
Corinne E Crosby1, Annette O'Connor1, Amelia S Munsterman1
1Department of Large Animal Clinical Sciences, Michigan State University College of Veterinary Medicine, Michigan State University, East Lansing, MI, United States.
在马群中,亚基过量 (ABE) 不能有效区分医疗和手术性结肠. 血清葡萄糖和L-乳酸盐水平是疾病严重程度和手术结果的更好指标.
科学领域:
- 动物医学
- 马体内科
- 诊断生物标志物
背景情况:
- 结肠是马匹死亡的常见原因,没有单一的生物标志物可以预测手术的必要性或死亡率.
- 在患有胃肠道疾病的马群中,没有对基过量 (ABE) 进行评估,这是一种潜在的代谢障碍指标.
研究的目的:
- 在出现胃肠疾病的马中评估ABE的诊断价值.
- 确定ABE是否可以区分医疗和手术性结肠,并预测生存结果.
主要方法:
- 585名马匹因急性胃肠疾病住院的回顾病例系列 (2019-2024年).
- 信号分析,体检结果,血液气体分析 (包括ABE) 和手术结果.
- 多变量分析以评估敏感性和特异性,以区分结肠类型和预测存活率.
主要成果:
- 在不存活的手术病例中,ABE较高,但没有可靠地区分医疗和手术结肠或存活结果.
- 血清葡萄糖水平是医学与手术结肠 (AUC=0. 76) 和杀性病变 (AUC=0. 81) 的最佳预测指标.
- 在手术后最好的预测寿命是年龄和血清L- 乳酸 (AUC=0. 76).
结论:
- ABE不是唯一可靠的诊断或多变量工具来确定马的严重程度或预后.
- 高血糖和高乳糖是患有胃肠疾病的马的疾病严重性的重要指标.
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