便免疫化学测试的诊断准确性,用于结肠镜检查的症状患者的分离:一个前性单中心研究
T Matthews1,2, M O'Sullivan1, A Billur3
1Department of Gastroenterology, St Luke's General Hospital, Kilkenny, Ireland.
Canadian journal of gastroenterology & hepatology
|September 2, 2025
概括
便免疫化学测试 (FIT) 显示在有症状的患者中检测结直肠癌的灵敏度为100%. 这项诊断准确性研究证实FIT是一种安全有效的分类工具,优化了内镜服务.
科学领域:
- 胃肠病学
- 诊断的准确性
- 结肠直肠癌查
背景情况:
- 便免疫化学测试 (FIT) 是NICE推用于初级护理中的症状患者的分类.
- 评估FIT在转诊结肠镜的症状患者的二次护理中的表现对于优化诊断途径至关重要.
- 由于资源有限,需要有效的分类工具来管理内镜服务需求.
研究的目的:
- 评估便免疫化学试验 (FIT) 在检测显著结肠直肠病理方面的诊断准确性.
- 评估FIT在二次护理环境中转诊结肠镜的症状患者的性能.
- 确定FIT作为优化内镜服务的分类工具的实用性.
主要方法:
- 一项前性诊断准确性研究,涉及1296名成年患者进行下胃肠内镜检查.
- 使用FIT套件,值≥50ng/ ml,需要紧急进行结肠镜检查.
- 结肠镜作为确定显著结肠直肠病理的参考标准.
主要成果:
- 1113名患者 (86%) 提供了有效的FIT结果,215名患者 (19%) 呈FIT阳性.
- FIT显示100%的敏感性和97-100%的结直肠癌负预测值.
- 在FIT阳性患者中,内镜检查的平均时间较短 (7 vs 21周).
结论:
- 便免疫化学测试 (FIT) 对结直肠癌的诊断具有很好的灵敏度.
- 对于有症状的患者来说,FIT可以作为安全有效的分类工具.
- 实施FIT可以帮助优化内镜服务,特别是在资源有限的环境中.
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