大胃多发性息肉的内镜下粘膜剖析:单一中心的临床病理学研究
Xiaobang Hu1, Julie C Fanburg-Smith2, Francesca M Ruggiero1
1Department of Pathology and Laboratory Medicine, Penn State Health Milton S. Hershey Medical Center, Penn State University College of Medicine, Hershey, USA.
Cureus
|September 2, 2025
概括
很难完全去除大胃多体 (GHP). 与内镜粘膜切除 (EMR) 或陷切除相比,内镜膜切除 (ESD) 的疗效更高,尽管复发率很高.
科学领域:
- 胃肠病学
- 透视外科手术
- 外科病理学
背景情况:
- 胃增生息肉 (GHP) 可能导致严重的临床问题,特别是当它们很大时,导致出血或阻塞.
- 虽然罕见,但在本研究中没有观察到恶性转变的GHPs.
- 了解大型GHP的行为和最佳管理对于患者的护理至关重要.
研究的目的:
- 通过内镜切除治疗的大型GHP (≥20毫米) 的临床病理特征.
- 对大型GHP进行不同内镜切除技术的疗效和复发率进行比较.
- 确定影响GHP成功根除和复发的因素.
主要方法:
- 在2013年至2020年间对接受内镜下粘膜切除 (ESD),内镜粘膜切除 (EMR) 或大 GHP 陷切除 (SR) 的患者进行了回顾性分析.
- 对临床病理特征,程序细节和随访内镜检测结果的审查.
- 切除样本的组织病理学检查,包括边缘状态和转化或失育的存在.
主要成果:
- 在使用ESD (n=16),EMR (n=15) 和SR (n=6) 的10名患者中进行了37次切除.
- 观察到高复发率:ESD为69. 2%,EMR为100%,SR为100%,平均随访时间为9. 4个月.
- 在完全切除中,ESD的成功率更高,在不复发的病例中,深度边缘为负,这表明场效应有助于侧边缘的复发.
结论:
- 由于内切除后的高复发率,大型GHP存在重大管理挑战.
- 内镜下粘膜切割 (ESD) 似乎比EMR或SR更有效地实现大GHP的完整切除.
- 复发,特别是在侧边缘,表明现场效应,突出显示了在病理过程中精确边缘评估的重要性,可能有助于手术内固定和涂墨.
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