牙干细胞对基于酸盐的水泥的体外反应:临床前证据的系统审查和元分析
Ishika Chatterjee1, Pratik Agrawal2, Yash Sinha3
1Department of Conservative Dentistry and Endodontics, Kalinga Institute of Dental Sciences, Bhubaneswar, IND.
Cureus
|September 2, 2025
概括
像MTA和Biodentine这样的基于酸盐的液压水泥促进人类牙干细胞 (hDPSC) 的再生. 这些生物活性物质增强了hDPSC的活力,迁移和牙的分化,这对于重要的脉疗法至关重要.
科学领域:
- 生物材料科学
- 复原医学
- 牙周内科
背景情况:
- 用干细胞和生物活性材料恢复牙髓活力.
- 人类牙真皮干细胞 (hDPSC) 由于其自我更新和牙产生潜力而具有关键作用.
- 像MTA和Biodentine这样的基于酸盐的液压水泥 (HCSCs) 被用于重要的纸疗法.
研究的目的:
- 通过元分析评估HCSCs对hDPSCs的细胞相容性和生物活性.
- 评估HCSC对hDPSC生存,繁殖,迁移,粘附和分化的影响.
- 综合现有的HCSC和hDPSC体外研究.
主要方法:
- 按照PRISMA指南进行系统审查和元分析.
- 在PubMed,Scopus和Web of Science (2014-2023) 的文献搜索.
- 使用RevMan 5. 3进行组合细胞活力数据的元分析;使用Cochrane ROB-2评估偏差风险.
主要成果:
- MTA,Biodentine,加速的MTA和CEM显著提高了hDPSC的活力,迁移和牙的分化.
- TheraCal LC显示有毒性,而TheraCal PT显示无毒性.
- 后分析显示对照组没有显著差异 (SMD - 0.26, p > 0.05);没有发现出版偏差.
结论:
- 通过促进积极的hDPSC生物结果,MTA,Biodentine,加速的MTA和CEM对再生性内牙有希望.
- 这些HCSC增强了细胞活力,迁移和分化潜力.
- 需要进一步的体内研究和临床试验,以优化再生内牙科的材料选择.
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