在卵子检测过程中氧化对体外受精结果的影响:一项回顾性研究
Shailendra Kumar1, Harshini Medikondu1, Dhruv Jain1
1Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, New Delhi, IND.
Cureus
|September 2, 2025
概括
在体外受精 (IVF) 取卵细胞的麻醉中使用的氧化 (N2O) 没有影响怀孕或分裂率. 然而,N2O暴露与更高数量的低质量的卵细胞相关.
科学领域:
- 生殖医学
- 麻醉学
- 胚胎学
背景情况:
- 氧化 (N2O) 经常用于体外受精 (IVF) 过程中的卵细胞检索麻醉.
- N2O可能通过禁用甲胺合成酶来干扰DNA合成,这可能会影响试管婴儿的结果.
- 有关N2O对植入和早期流产的影响存在担忧.
研究的目的:
- 评估单独使用异氨酸对异氨酸加N2O对IVF结果的影响.
- 为了比较两个麻醉剂组之间的怀孕,受精,卵细胞质量和分裂率.
主要方法:
- 对250名接受试管婴儿手术的患者进行回顾性分析.
- 患者使用异氨酸+N2O或仅用异氨酸进行麻醉.
- 关键IVF指标的比较,包括怀孕,受精,卵细胞等级和分裂率.
主要成果:
- 两组之间没有观察到怀孕或裂变率的显著差异 (第二天和第三天).
- 仅使用异黄素的受精率在数值上更高,但这种差异在统计学上并不显著.
- 与仅服用异黄素的组相比,N2O组中获得的3级卵细胞比例显著增加.
结论:
- 在试管婴儿中,包括氧化在内的麻醉并没有对受精,分裂或怀孕率产生不利影响.
- 使用N2O可能会增加低质量的卵细胞的获取.
- 仅用异氨酸麻醉可能是一个可行的替代方案,尽管它对卵细胞质量的影响需要进一步研究.
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