石榴对伤口愈合的影响
Ilkay Halicioglu1, Nilgün Isiksacan2, Firat Baytekin3
1Gastrointestinal Surgery, University of Health Sciences, Gazi Yasargil Training and Research Hospital, Diyarbakir, TUR.
Cureus
|September 2, 2025
概括
在败血症模型中,石榴提取物可以改善伤口愈合并减少肝损伤. 预败血症治疗显示出最有前途的结果,这表明败血症患者的潜在治疗益处.
科学领域:
- 生物医学研究
- 药理学
- 伤口愈合研究
背景情况:
- 败血症会影响伤口愈合,并通过全身炎症导致器官损伤.
- 石榴 (Punica granatum) 提取物富含抗氧化剂,具有抗炎和组织愈合的潜力.
研究的目的:
- 在毒模型中研究石榴提取物对伤口愈合的影响.
- 评估石榴提取物的使用时间 (毒前与毒后).
主要方法:
- 在Wistar大鼠中引起的血症 (n=38).
- 这些组包括假药,败血症,败血症前石榴和败血症后石榴治疗.
- 生物化学 (ALT,AST,尿素,肌) 和组织病理参数在手术后的第7天进行评估.
主要成果:
- 预毒性石榴治疗显著降低了氨酸酶 (ALT) 水平.
- 毒症后使用石榴可显著降低肌水平.
- 前毒性石榴的使用导致较低的颗粒组织得分,表明愈合改善.
结论:
- 红提取物在败血症前使用可能会防止败血症引起的肝损伤.
- 石榴提取物显示出作为辅助治疗的潜力,以支持败血症的伤口愈合.
- 这种天然产品在治疗败血症方面具有治疗效益.
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