晚期大脑衰老影响了慢性中风中心血管健康和失言症严重程度之间的关系
Natalie Busby1, Ida Rangus1, Nicholas Riccardi1
1Department of Communication Sciences and Disorders, University of South Carolina, Columbia, SC, USA.
Aging brain
|September 2, 2025
概括
通过加速大脑衰老, 心血管健康影响中风失语恢复. 在慢性中风患者中,保持身体健康可以改善大脑结构,并减少失言症的严重程度.
科学领域:
- 神经科学
- 心脏病学
- 语音病理学
背景情况:
- 心血管 (CV) 风险因素与脑部变化和中风失语症的恢复有关.
- 心血管健康,大脑衰老和语法障碍严重程度之间的确切关系尚不清楚.
研究的目的:
- 研究晚期大脑衰老在慢性中风患者的心血管健康和失言症严重程度之间的关系.
- 探索心血管风险如何影响中风后的大脑结构和语言恢复.
主要方法:
- 九十五名患有慢性中风失语症的参与者接受了行为测试 (西方失语电池失语率 - WAB AQ) 和核磁共振扫描.
- 使用BrainAgeR计算大脑年龄,比例大脑年龄 (PBA) 代表估计年龄和时间年龄之间的差异.
- 计算了心血管风险评分,并检查了血管评分,WAB AQ和PBA之间的关系.
主要成果:
- 较高的心血管风险与失言症的严重程度 (WAB AQ降低) 和大脑晚年衰老 (PBA增加) 相关.
- 晚期大脑衰老 (增加PBA) 独立地与更严重的失言症有关.
- 调解分析证实,较高的心血管风险导致大脑老化,这反过来加重了语盲症的严重程度,表明部分调解效应.
结论:
- 晚期大脑衰老部分影响心血管风险因素对慢性中风的失语严重程度.
- 保持心血管健康对于保持大脑完整性和可能改善中风幸存者的语言恢复至关重要.
- 促进身体健康,运动和饮食的干预措施可能是长期中风管理和语盲治疗的重要组成部分.
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