跨气候的精准营养:从南亚到北极的解码饮食,传统和基因组适应
Ajai Kumar Pathak1,2, Anna Kolesnikova2, Deepika Uttam Sambreker3
1Estonian Biocentre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Frontiers in nutrition
|September 2, 2025
概括
人类对饮食的遗传适应在不同人群之间有很大差异,例如南亚人和北极人,影响慢性疾病的风险. 基于基因组的个性化营养策略对于精确的健康至关重要.
科学领域:
- 人类进化生物学
- 营养科学
- 微生物组研究
背景情况:
- 人类群体表现出对不同饮食和环境的遗传适应.
- 在热带 (南亚) 和极寒 (北极) 种群之间观察到不同的适应性.
- 饮食变化影响基因-饮食-微生物组相互作用和慢性疾病风险.
研究的目的:
- 探索南亚和北极地区人口的遗传,饮食和微生物群适应性.
- 将高碳水化合物 (南亚) 与高脂肪/蛋白质 (北极) 饮食的适应情况进行比较.
- 了解通过精确健康预防慢性疾病的含义.
主要方法:
- 对与饮食相关的遗传适应性进行审查.
- 传统饮食和微生物组合的分析.
- 基因-饮食-微生物群相互作用的比较.
主要成果:
- 南亚人已经适应了植物性,高碳水化合物饮食.
- 北极种群适应海洋/动物,高脂肪/蛋白质饮食.
- 现代饮食破坏了祖先的互动,增加了慢性疾病的风险.
结论:
- 基因组营养策略必须考虑遗传多样性和当地环境.
- 了解基因-饮食-微生物组相互作用是预防饮食相关疾病的关键.
- 营养,文化和遗传学交叉形成特定人群的健康结果.
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