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在难民中治疗耐药性慢性PTSD后加强认知控制:可行性研究

Mirjana Askovic^1,2,3, Sejla Murdoch^1,2, René Mayer-Pelinski^4,5

¹Neurofeedback Services, New South Wales Service for the Treatment and Rehabilitation of Torture and Trauma Survivors (STARTTS), Sydney, NSW, Australia.

Frontiers in psychiatry

|September 2, 2025

概括

神经反治疗 (NFT) 改善了难民的创伤后应激障碍 (PTSD) 症状和认知控制. 参与者脑部活动正常化,表明NFT

科学领域:

神经科学
精神病学
临床心理学

背景情况:

在全球范围内,创伤后应激障碍 (PTSD) 患病率为3.9%,难民患病率更高 (23-42%).
认知控制缺陷是PTSD的核心特征,有助于治疗耐药性 (25-60%的病例).

研究的目的:

研究神经反疗法 (NFT) 治疗难民中PTSD症状和认知控制缺陷的有效性.
确定与治疗反应相关的神经生理标志物.

主要方法:

47名患有慢性抗治疗PTSD的难民在7个月内接受了与创伤辅导相结合的个性化NFT (中位数为26次).
治疗前后的评估包括哈佛创伤问卷 (HTQ) 和Go/No-Go任务中的事件相关潜力 (ERP).

主要成果:

受试者 (n=22) 显示P3d幅度正常化,表明认知控制得到改善.
非响应者 (n=25) 的ERP变化较小,基线慢正波 (SPW) 异常较大,这表明认知处理晚期受损.
基线SPW预测了治疗反应.

结论:

在抗治疗的难民群体中, NFT 可以缓解创伤后应激障碍的症状并增强认知控制.
治疗反应与P3d波形正常化有关.
建议通过随机对照试验和更大的样本进行进一步的研究.

关键词:

慢性创伤后应激障碍认知控制与事件相关的潜力神经反神经标志物难民创伤

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