相关实验视频

Updated: May 5, 2026

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Published on: March 5, 2018

以人工智能为基础的预测模型,用于经过血型细胞移植的急性髓性白血病患者的复发

Shuang Fan¹, Haoyang Hong^2,3, Shengye Lu¹

¹Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China.

Journal of translational internal medicine

|September 2, 2025

概括

这项研究开发了一种AI模型,用于预测急性髓性白血病 (AML) 患者的复发情况,这些患者接受了与异位捐赠者 (HID) 相关的干细胞移植. 该PKU-AML模型有助于早期检测和治疗复发,从而改善患者的治疗结果.

科学领域:

血液学
癌症学
医学的人工智能

背景情况:

复发是急性髓性白血病 (AML) 患者移植失败的主要原因.
早期准确预测移植后复发对于有效的患者管理和改善移植成功率至关重要.

研究的目的:

开发和验证基于人工智能 (AI) 的预测模型,用于接受HID HSCT的AML患者的移植后复发.
为早期识别高复发风险患者提供可靠的工具.

主要方法:

一项回顾性队列研究,包括接受HID HSCT的完全缓解的AML患者 (年龄≥12岁).
使用培训队列 (70%) 开发预测模型和名录,并在单独的队列 (30%) 和独立的队列 (n=213) 中进行验证.
包括五个关键变量:AML风险类别,CR的诱导化疗疗程,疾病状态,HSCT前可测量的残留疾病和血型差异.

主要成果:

开发的PKU-AML模型包含了五个重要的预测变量.
该模型表现出良好的匹配性 (霍斯默-莱梅肖P=0.205) 和预测准确性 (一致性指数=0.707).
在多个群体和临床实践中的验证证实了nomogram的可靠性和临床实用性.

结论:

在CR中接受HID HSCT的AML患者中,PKU- AML模型有效预测AML复发.
这种人工智能驱动的工具有助于在移植后复发的早期预测和及时干预.
该模型为临床医生提供了宝贵的资源来管理复发风险并优化患者护理.

关键词:

急性骨髓性白血病一样的人血造干细胞移植干扰素-α 预防性复发的情况

更多相关视频

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

Simplified Intrafemoral Injections Using Live Mice Allow for Continuous Bone Marrow Analysis

Simplified Intrafemoral Injections Using Live Mice Allow for Continuous Bone Marrow Analysis

Published on: November 10, 2023

相关概念视频

iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...