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缺乏原发动性皮层的小鼠的自愿和强迫跑步能力

Ryusei Abo¹, Mei Ishikawa¹, Rio Shinohara¹

¹Laboratory of Brain Development and Regeneration, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.

Frontiers in neural circuits

|September 2, 2025

概括

在小鼠中训练高速跑步时, 主要运动皮层并非必不可少. 然而, 移除它会影响自发的跑步行为.

科学领域:

神经科学
发动机控制
动物的行为

背景情况:

随意和强迫的运动控制涉及复杂的大脑区域协调.
主要运动皮质在熟练跑步中的具体作用在很大程度上仍未确定.

研究的目的:

研究主要运动皮层对于训练高性能跑步的必要性.
要区分主运动皮层移除对自愿与强迫运动的影响.

主要方法:

训练小鼠在轮子上进行高性能运行 (>10,000次/天).
进行了双边皮质切除,包括主要运动皮质.
对自愿和强制运行任务进行了测试.

主要成果:

与虚假对照相比,皮层损伤延迟了自愿运行的恢复.
在高速跑步机上跑步的性能没有受到皮质损伤的显著影响.
皮质损伤的小鼠在跑步开始时自发性降低.

结论:

主要运动皮质并不严格要求执行训练的快速运行.
主要运动皮质在自发启动跑步行为中起着重要作用.

关键词:

大脑皮层损伤发动机控制跑步轮跑步机

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