相关实验视频

Updated: Sep 9, 2025

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Published on: December 9, 2022

TM9SF1作为毒症严重性和死亡率的新预后生物标志物:一项纵向研究

Ke Wang^1,2,3, Lu Zhang^1,2,3, Fengqiao Zhou^1,2,3

¹Institute of Neuroscience and Brain Diseases, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, People's Republic of China.

Journal of inflammation research

|September 2, 2025

概括

超膜9家族成员1 (TM9SF1) 在败血症中升高,表明严重程度和死亡率较高. TM9SF1显示为早期毒症检测和预后的新生物标志物.

科学领域:

生物化学
免疫学
危急护理医学

背景情况:

败血症是重症监护室常见的一种危及生命的疾病.
早期发现败血症的严重程度和预后对于患者的结果至关重要.
超膜9家族成员1 (TM9SF1) 正在研究其在败血症中的作用.

研究的目的:

评估TM9SF1作为潜在的败血症严重性和死亡率的早期指标.
将TM9SF1的预测性能与现有的临床标志物进行比较.
开发使用TM9SF1的败血症严重性和死亡率预测模型.

主要方法:

在周围血液单核细胞 (PBMC) 中量化了TM9SF1和细胞因子的基因表达.
使用接收器操作特征 (ROC) 曲线分析来评估TM9SF1的预测值.
构建了一个基于TM9SF1和其他临床标志物的预测模型.

主要成果:

与败血症患者和健康对照患者相比,患有败血症的患者的TM9SF1mRNA表达显著更高.
升高的TM9SF1水平与败血症的严重程度和死亡率的增加相关.
与CRP,氧化指数和乳酸相比,TM9SF1对败血症严重性和死亡率的预测准确度更高.

结论:

增加的TM9SF1水平与更严重的败血症和死亡率有关.
TM9SF1通过影响细胞因子的产生来调节败血症的炎症.
TM9SF1代表了早期毒症检测和预后的潜在新型免疫生物标志物.

关键词:

没有.对炎症进行调节编号模型感染性疾病严重程度

更多相关视频

A Data-Driven Approach to Quantifying Immune States in Sepsis

A Data-Driven Approach to Quantifying Immune States in Sepsis

Published on: February 7, 2025

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia

Published on: June 28, 2018

相关概念视频

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...