在口腔状细胞癌患者的术后预后分层中修改的那不勒斯预后得分
Jingyi Ran1, Yalian Liu1, Xiaoxi Yi1
1Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Journal of inflammation research
|September 2, 2025
概括
一个新的修改的那不勒斯预后分数 (mNPS) 显示了口腔状细胞癌 (OSCC) 的预后准确性. 这种修改的分数有助于更好地分类OSCC患者的风险.
科学领域:
- 癌症学
- 生物统计学
- 癌症研究
背景情况:
- 那不勒斯预后分数 (NPS) 是各种癌症的验证预后指数.
- 它在口腔状细胞癌 (OSCC) 中的特殊功效需要进一步研究.
- 已建立的指数可能无法完全捕捉OSCC特定的预后因素.
研究的目的:
- 开发和验证适用于OSCC的修改后的NPS (mNPS).
- 将mNPS的预后性能与传统的NPS和其他指数进行比较.
- 提高OSCC患者的风险分层.
主要方法:
- 一组479名接受治疗手术的OSCC患者被分为发展 (n=335) 和验证 (n=144) 组.
- 确定血清白蛋白 (ALB),总胆固醇 (TC),中性细胞与淋巴细胞的比率 (NLR) 和淋巴细胞与单细胞的比率 (LMR) 的群体特异性最佳切断值.
- 使用ROC分析,C指数和考克斯回归来评估预测性表现,并构建并验证名图.
主要成果:
- 在OSCC中,修改后的NPS (mNPS) 被确定为总生存率 (OS) 的独立预测因子.
- 与传统的NPS模型相比,基于mNPS的诺图表显示出更高的预后准确性 (AUC范围为0. 80至0. 83).
- 校准和决策曲线分析证实了mNPS名谱的稳定性和临床实用性.
结论:
- 对OSCC特定特征的重新校准值改善了mNPS的预后歧视.
- 对于OSCC来说,mNPS提供了增强的个性化风险分层.
- 在OSCC管理中,mNPS是临床决策的实用工具.
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