接受脏移植的人群感染模式和生存率
Dalvi Sayali Vishnu1, Parag Tilve1, Sachin Yadav Bodke2
1Department of Nephrology, Bombay Hospital Institute of Medical Sciences, India.
Indian journal of nephrology
|September 2, 2025
概括
移植后的感染,包括细菌,病毒和COVID-19,会影响存活率. 有效的管理策略可以减轻感染风险,使患者和移植的存活率与西方数据相比较.
科学领域:
- 肝脏病学
- 移植免疫学
- 传染性疾病
背景情况:
- 感染是移植后移植和患者存活的主要决定因素.
- 由于印度的数据有限,COVID-19疫情对移植患者产生了重大影响.
- 了解移植后感染对于改善结果至关重要.
研究的目的:
- 分析移植后感染的类型和对印度移植患者的患者和移植存活率的影响.
- 评估包括BK病毒和COVID-19在内的特定感染与移植损失的关联.
- 在感染负担的背景下评估患者和移植的整体生存率.
主要方法:
- 追溯的观察研究.
- 在2014年10月至2021年10月期间从移植患者收集的数据.
- 使用卡普兰-梅尔生存分析.
主要成果:
- 在118名患者中发生了255次感染;细菌感染最常见 (55%).
- 尿路感染 (70.5%) 和COVID-19 (56%) 分别是最常见的细菌和病毒感染.
- BK病毒和COVID-19与移植损失的增加有关;COVID-19导致了大多数感染相关的死亡. 一年,三年和五年的患者存活率为98. 23%,96. 36%,92. 90%;移植存活率为98. 14%,95. 97%,91. 78%.
结论:
- 对于接受移植的人来说,感染仍然是一个重大问题.
- 尽管感染负担很高,COVID-19 流行病,但患者和移植的存活率与西方数据相比较.
- 有效的感染管理策略对于减少感染对生存的影响至关重要.
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