患有经常复发和类固醇依赖性脏综合征的儿童的内皮功能障碍
Rajesh Verma1, Bobbity Deepthi2, Abhijeet Saha1
1Division of Pediatric Nephrology, Department of Pediatrics, Lady Hardinge Medical College, New Delhi, India.
Indian journal of nephrology
|September 2, 2025
概括
患有经常复发或类固醇依赖性性综合征的儿童在复发期间会出现内皮功能障碍. 随着治疗,生物标志物水平下降,表明疾病活动影响了血管健康.
科学领域:
- 儿童脏病学
- 儿童的心血管健康
- 内皮功能研究
背景情况:
- 在儿童中,经常复发的 (FR) 和类固醇依赖的 (SD) 性综合征 (NS) 与内皮功能障碍和损伤有关.
- 这种功能障碍增加了动脉样硬化和心血管不良事件的风险.
- 了解这些血管变化对于管理长期健康结果至关重要.
研究的目的:
- 在FRNS和SDNS复发期间检测血中的内皮功能障碍标记物,可溶性E-选择素 (sE-选择素) 和血管细胞粘附分子-1 (VCAM-1).
- 在复发和缓解期间与健康对照对比FRNS/SDNS的儿童的标记水平.
主要方法:
- 在复发时注册了56名被诊断为FRNS或SDNS的儿童 (年龄为1-16岁).
- 在复发期间采集血样本,并在类固醇诱导缓解后长达六周进行跟踪.
- 在患者和同等数量的对照人群中测量和比较sE-selectin和VCAM- 1水平.
主要成果:
- 在FRNS/ SDNS的儿童中,血sE选择素和VCAM-1水平在复发期间显著升高 (p < 0. 0001).
- 这些标志物水平在类固醇诱导缓解六周后显著下降,与对照水平相比较.
- 与对照组相比,在复发期间观察到血清总胆固醇和甘油三的升高,即使在缓解后也持续存在 (p < 0. 0001).
结论:
- 在FRNS和SDNS的儿童中,内皮功能障碍在复发期间得到证实.
- 内皮功能障碍的程度似乎在很大程度上取决于综合征的活性.
- 这些发现强调了监测FRNS/SDNS儿童心血管风险因素的重要性.
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