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在盲人阅读研究中,VisR超声波通过弹性图与B模式比改善了乳腺癌的诊断
Anna V Phillips1, Cherie M Kuzmiak2, Gabriela Torres3
1Lampe Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, North Carolina State University, Chapel Hill, NC 27514 USA.
概括
使用粘度和刚度图像的弹性图与B模式比率 (E/B) 可以更好地检测乳腺癌. 结合粘弹性反应 (VisR) 超声波指标可以提高恶性病变的诊断准确性.
科学领域:
- 医学成像
- 生物物理
- 癌症学
背景情况:
- 超声波对乳腺癌的诊断有助于乳房检查,
- 弹性图与B模式的比率 (E/B) 可以区分恶性 (E/B > 1) 和良性 (E/B < 1) 的乳腺质量.
- 粘度是恶性瘤的新兴生物标志物,其在E/B分析中的作用尚未被探索.
研究的目的:
- 从粘弹性响应 (VisR) 超声波中获得的E/B诊断值,包括度和粘度.
- 评估粘度测量是否可以提高E/B的准确性,以区分恶性和良性乳腺病变.
主要方法:
- 使用粘弹性反应 (VisR) 超声波来获得相对刚度 (RE) 和相对粘度 (RV) 的图像.
- 一项盲读者研究比较了来自刚度,粘度和综合指标的E/B值.
- 曲线下的面积 (AUC) 用于评估对声辐射力冲动 (ARFI) 峰值位移的诊断性能.
主要成果:
- 粘度图像中的E/B值显示出与度图像相似的趋势,区分恶性 (> 1) 和良性 (< 1) 病变.
- 使用RE,RV或两者计算的E/B,与单独使用ARFI峰值位移的E/B相比,AUC高出4 - 16%.
- 结合粘度和弹性指标显示出更高的诊断准确性.
结论:
- 通过结合粘度,粘弹性反应 (VisR) 超声波提高了乳腺癌检测的E/B比率的诊断效用.
- 将VisR衍生的粘度和弹性指标整合到E/B计算中,显著提高了分辨恶性乳腺病变的准确性.
- 这种方法为非侵入性乳腺癌诊断带来了有前途的进展.
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