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超越化疗:探索树根和纳米酸用于神经保护

Chuangen Li¹, Sriram Kaliamoorthy², Mariappan Vijayalakshmi³

¹Department of Rehabilitation Medicine, Ankang People's Hospital, Ankang, 725000, China.

Iranian journal of basic medical sciences

|September 2, 2025

概括

新型树根和纳米酸盐复合物 (TRE@NHA) 在治疗化疗引起的外周神经病变 (CIPN) 中具有前景. 在体外和体内,TRE@NHA-2 显示出显著的抗炎,抗氧化和神经保护作用.

科学领域:

生物材料科学
神经药理学
纳米技术

背景情况:

化疗诱导的周围神经病变 (CIPN) 是癌症治疗的一个衰弱的副作用.
目前对CIPN的治疗方法有限,并且经常伴有显著的副作用.
迫切需要新的治疗策略来管理和预防CIPN.

研究的目的:

合成和描述新型树根和纳米酸 (TRE@NHA) 复合物.
评估TRE@NHA复合剂在减轻神经炎症和氧化应激方面的实验疗效.
在CIPN的老鼠模型中研究TRE@NHA复合物的体内治疗潜力.

主要方法:

使用FTIR,XRD,TGA和HRTEM合成和表征TRE@NHA复合材料.
在体外研究中使用PC12细胞来评估细胞毒性,抗炎作用和神经保护性.
使用帕克利塔塞尔 (PTX) 诱导CIPN的体内大鼠模型,随后进行行为,组织病理和氧化应激标记评估.

主要成果:

TRE@NHA复合材料成功将树根 (TRE) 整合到纳米酸盐 (NHA) 基质中.
在体外,TRE@NHA-2 显示出显著的抗炎和神经保护作用,抑制细胞因子的产生并增强细胞活力.
在体内,TRE@NHA-2有效地缓解了帕克利塔塞尔引起的神经病痛,减少了神经元损伤,并在坐骨神经组织中表现出强大的抗氧化特性.

结论:

新的TRE@NHA复合材料成功开发和特征化.
TRE@NHA-2具有显著的抗炎,抗氧化和神经保护性质.
在缓解化疗引起的外周神经病变方面,TRE@NHA-2具有有前途的治疗潜力.

关键词:

抗氧化剂水氧亚帕纳米颗粒神经性疼痛树木黄根

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