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金属纳米颗粒在口腔炎症中的应用

Mingzhen Yang¹, Mingyu Sun², Jiarui Wang¹

¹School of Stomatology, Henan University, Kaifeng, China; Kaifeng Key Laboratory of Periodontal Tissue Engineering, Kaifeng, China.

International dental journal

|September 2, 2025

概括

金属纳米颗粒 (MNP) 为口腔炎症提供创新解决方案,有效打击病原体并调节免疫反应. 这些纳米材料有望为向药物和个性化治疗提供帮助, 克服传统治疗的局限性.

科学领域:

生物材料科学
纳米技术
口腔医学

背景情况:

口腔炎症是一个全球性的健康挑战,常规治疗选择有限.
抗生素耐药性,药物供应不良以及免疫抑制副作用需要新的治疗策略.
金属纳米颗粒 (MNP) 具有独特的抗菌和免疫调节特性,对口腔健康有益.

研究的目的:

在过去五年中审查主要MNP (Ag,Cu/CuO,Au,TiO2,Zn/ZnO,CeO2) 在口腔炎症疾病中的机制和应用.
探索MNP在病原体无活化,免疫反应调节和向药物输送方面的潜力.
讨论MNP在口腔炎症治疗中的挑战和未来前景.

主要方法:

专注于过去五年出版的文献综述.
对各种金属纳米粒子 (Ag,Cu/CuO,Au,TiO2,Zn/ZnO,CeO2) 的作用机制的分析.
检查MNP在口腔炎症疾病中的临床前应用.

主要成果:

在消灭口腔病原体和调节宿主免疫反应方面,MNP具有有效性.
纳米颗粒的特性可以提高药物向性,从而提高治疗精度.
在临床前和临床环境中,各种MNP对口腔炎症有显著的潜力.

结论:

在治疗口腔炎症方面, 金属纳米颗粒为推进个性化和精确医学提供了有前途的途径.
解决临床翻译方面的挑战对于实现多种疗法的全部潜力至关重要.
在口腔炎症的传统治疗中,MNP是显著的进步.

关键词:

抗菌性临床转化中的挑战免疫调节金属纳米粒子牙周炎反应性氧物种

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