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产前接触稀土元素与早产之间的联系:结合出生队列和体外研究的见解

Zhongqiang Cao¹, Ziwen Kong¹, Hongjian Gong¹

¹Institute of Maternal and Children Health, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji medical college, Huazhong University of Science & Technology, Wuhan, China.

Environment international

|September 2, 2025

概括

稀土元素与早产风险增加有关. 暴露于,和加多等REEs可能会通过影响热囊细胞和基因表达来损害胎儿的发育.

科学领域:

环境健康
生殖毒理学
流行病学

背景情况:

稀土元素越来越多地被认为是环境污染物.
REEs对早产 (PTB) 的影响和潜在的生物机制尚不清楚.

研究的目的:

研究母体尿路REE暴露与PTB风险之间的关联.
探索REE对热囊细胞的机械效应,并确定REE诱导PTB的潜在生物途径.

主要方法:

分析了来自中国的4897对母婴对,测量了母亲尿液中的13个REE.
用物流回归和加权量积 (WQS) 模型来评估与 REE 暴露相关的 PTB 风险.
使用HTR-8/SVneo热囊细胞进行体外研究,以评估REE治疗后的入侵,MMP-9/TIMP-1表达和转录形状.

主要成果:

在患有PTB病例的母亲中观察到12个REEs的较高度和检测频率 (P < 0. 05).
增加母体对单个和混合REEs的暴露与每log2单位增加的PTB风险增加18- 51%.
(Ce), (Pr) 和 (Gd) 被确定为PTB风险的主要因素.
环境相关的REE度增强了热囊细胞入侵,提高了MMP-9的调节,并抑制了TIMP-1.
转录组分析显示了1425个差异表达的基因,影响了核糖体生物发生和氧化酸化.

结论:

孕产妇暴露于REEs与早产风险的增加有关.
REEs可能会通过涉及MMP-9/ TIMP-1调节和关键细胞过程改变的途径对热囊细胞功能产生不利影响.
调查结果强调REEs是影响母胎健康的重要环境污染物,并表明需要重新评估当前的暴露指南.

关键词:

群组研究混合效应过早出生稀土元素热囊细胞的入侵

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