SNC:基于高通量测序的小型非编码RNA的综合数据库
Xiaoqiang Lang1, Jinjing Luo2, Fazhi Li1
1Microbiology and intelligent biomanufacturing Key Laboratory of Sichuan Province, College of Life Science, Sichuan University, Chengdu, Sichuan 610041, China.
Journal of advanced research
|September 2, 2025
概括
FungiSNC是第一个针对真菌小非编码RNA (sncRNA) 的综合数据库,提供全面的分析工具. 这一平台有助于了解的sncRNA功能和调节网络,用于抗真菌和生物控制应用.
科学领域:
- 菌群学
- 生物信息学
- 基因组学
背景情况:
- 小型非编码RNAs (sncRNAs) 是真菌发育,应激反应和致病性的重要调节者.
- 现有的数据库缺乏对真菌sncRNA测序数据的全面整合和分析能力.
- 目前没有针对真菌sncRNA及其功能的专用平台.
研究的目的:
- 建立FungiSNC,这是第一个关于真菌sncRNA的综合数据库.
- 为真菌中的各种sncRNA类别提供一个全面的平台.
- 促进真菌sncRNA功能的分析和探索.
主要方法:
- 公共和内部sRNA-seq数据集的数据预处理的标准化工作流程.
- 系统检测,分类和功能注释sncRNAs.
- 将结果集成到具有嵌入式分析工具的关系数据库中.
主要成果:
- FungiSNC 是一个关于真菌sncRNA的综合数据库.
- 它包括不同的sncRNA类别:siRNAs,milRNAs,phasiRNAs,rRNAs,tRNAs,snRNAs,snoRNAs,piRNAs和tRFs.
- 该数据库汇总了29种真菌的989个NGS样本.
结论:
- FungiSNC是用于真菌sncRNA数据策划,注释和功能分析的首个平台.
- 它将碎片化数据与计算工具结合起来, 探索真菌中的sncRNA调节网络.
- 这些发现对抗真菌疗法和农业生物控制策略有影响.
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