肥胖,新陈代谢健康和大脑健康:前性队列研究的见解
Meng Wang1, Lan Yu1, Zonghang Tong2
1Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin Medical University, Tianjin, China.
Journal of affective disorders
|September 2, 2025
概括
代谢健康的肥胖会增加中风,焦虑和抑郁的风险. 痴呆风险与代谢不健康有关, 而不是肥胖本身,
科学领域:
- 神经学
- 代谢健康
- 肥胖问题研究
背景情况:
- 代谢健康的肥胖与心血管风险有关,但其对神经和精神健康的影响尚不清楚.
- 这项研究调查了代谢肥胖现象与与大脑相关的疾病之间的联系.
研究的目的:
- 探索不同代谢肥胖现象与神经和心理健康障碍的风险之间的联系.
- 澄清代谢健康和肥胖在大脑健康结果中的作用.
主要方法:
- 一项以人口为基础的前性队列研究,对318,103名英国生物库参与者进行了中位数 13. 2年的随访.
- 由BMI≥30kg/ m2和6个代谢生物标志物中的≥4个定义的代谢健康肥胖症 (MHO).
- 考克斯回归模型分析了代谢肥胖现象与中风,焦虑,抑郁,双相情感障碍,痴呆和帕金森病 (PD) 等结果之间的关联.
主要成果:
- 与代谢健康的非肥胖者相比,代谢健康的肥胖者患中风 (HR 1. 11),焦虑 (HR 1.16) 和抑郁 (HR 1.43) 的风险显著增加.
- 代谢不健康的非肥胖者 (MUN) 和代谢不健康的肥胖者 (MUO) 群体也存在中风,焦虑和抑郁的风险.
- 在65岁以下的MUN和MUO群体中观察到痴呆的风险增加,与代谢不健康有关,而不是仅仅与肥胖有关.
结论:
- MHO和MUO都与中风,焦虑和抑郁症的风险显著增加有关.
- 不管肥胖状况如何,痴呆风险似乎与代谢不健康状况更为密切相关.
- 维持新陈代谢健康和正常体重对于改善整体大脑健康至关重要.
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