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美国男性的细颗粒物暴露和精子DNA碎片化:一个空间横截面研究

Yuval Fouks^1,2, Denis A Vaughan^3,4, Pietro Bortoletto^3,4

¹Boston IVF-IVIRMA Global Research Alliance, Waltham, MA, USA.

Human reproduction (Oxford, England)

|September 2, 2025

概括

暴露于细颗粒物 (PM2.5) 会增加精子DNA的碎片化,尤其影响社会经济地位较低的男性. 这突显了空气污染和社会不平等对生殖健康的影响.

科学领域:

环境健康
生殖毒理学
精子生物学

背景情况:

环境空气污染物,包括细颗粒物 (PM2.5),与不良的生殖结果有关.
对于PM2.5对精子染色质完整性的影响尚不清楚,特别是考虑到社会人口因素.

研究的目的:

调查暴露于细颗粒物 (PM2.5) 和精子DNA碎片化的关系.
通过社会经济地位 (SES) 和年龄来探索潜在的影响.

主要方法:

对接受生育评估的男性的21851个精液样本进行截面研究 (2005-2022年).
使用卫星衍生模型估计的PM2.5暴露.
用于评估PM2.5与精子DNA碎片化指数 (DFI) 之间的关联的空间线性混合效应模型,对共变量进行调整并测试相互作用.

主要成果:

较高的PM2.5暴露与精子DNA碎片化 (DFI) 的增加显著相关.
观察到一种非线性剂量反应模式,其效果达到11μg/ m3左右.
与PM2.5相关的DFI增加较大,而年龄 (≥50岁) 也是DFI升高的强有力的预测因素.

结论:

暴露于PM2.5会对精子染色质产生负面影响,对来自较低SES背景的男性产生不成比例的影响.
结果表明精子DNA碎片化可以作为环境和社会压力的生物标志物.
结果支持针对空气污染和生殖健康方面的社会不平等措施.

关键词:

大气污染流行病学细颗粒物男人的生育能力社会经济差异精子DNA碎片化

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