90天以下婴儿的简单疹病毒疾病:英国儿科监测部门的研究
Julia R R Dudley1, Annalie Shears2,3,4, Georgina Yan1,5
1Academic Department of Paediatrics, Royal Alexandra Children's Hospital, Brighton, West Sussex, UK.
Archives of disease in childhood
|September 2, 2025
概括
在90天以下的婴儿中,新生儿感染简单疹病毒 (HSV) 是常见的,延迟治疗导致结果不佳. 早期的经验测试和治疗对不健康的新生儿至关重要.
科学领域:
- 新生儿感染
- 病毒学
- 流行病学
背景情况:
- 新生儿感染简单疹病毒 (HSV) 对健康构成重大风险.
- 了解新生儿HSV的发病率和临床谱对于有效的治疗至关重要.
研究的目的:
- 估计英国和爱尔兰90天以下婴儿的HSV感染率.
- 描述新生儿HSV感染的临床表现和结果.
主要方法:
- 基于人口的前性国家监测研究.
- 使用英国儿科监测单位 (BPSU) 的方法.
- 在2019年8月至2022年2月期间被证实感染HSV的90天以下的婴儿.
主要成果:
- 在每10万活产婴儿中发现6.0例.
- 观察到传播性疾病 (32. 5%),中枢神经系统疾病 (35%) 和SEM疾病 (32. 5%).
- 报告高死亡率 (23. 9%) 和神经发育障碍 (29. 3% 在24个月),治疗延迟很常见.
结论:
- 新生儿的HSV可能不典型,没有发烧或皮肤病变,导致治疗延迟.
- 结果仍然很差,病例死亡率和长期发病率很高.
- 临床医生应保持在新生儿的HSV经验测试和治疗的低门.
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