沙特阿拉伯的宫癌风险和高风险HPV类型分布:国家实验室研究的趋势
Hamsa J Banjer1, Hossam H Tayeb1, Khalid J Alzahrani1
1From the Department of Clinical Laboratory Sciences (Banjer, Alzahrani), College of Applied Medical Sciences, Taif University, Department of Histopathology (Alsufiani), King Faisal Medical Complex, Taif. From the Nanomedicine Unit (Tayeb), Center of Innovation in Personalized Medicine, King Abdulaziz University, Jeddah. From the Department of Medical Laboratory Sciences (Tayeb), Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah. From the Department of Pathology (Alrowaihi), Al Borg Medical Laboratories, Al Borg Diagnostics, Jeddah, Kingdom of Saudi Arabia.
沙特阿拉伯的人类乳头瘤病毒 (HPV) 患病率显示出明显的年龄和地区差异. 非16/18基因型是常见的,强调了针对子宫癌的预防和监测策略的需要.
科学领域:
- 癌症学
- 病毒学
- 公共卫生
背景情况:
- 高风险的人类乳头瘤病毒 (HPV) 感染是全球性宫癌的主要原因.
- 了解HPV基因型分布和流行率对于制定有效的预防策略至关重要.
研究的目的:
- 分析沙特阿拉伯HPV基因型的分布.
- 确定与HPV感染相关的区域趋势和细胞学异常.
- 为该地区的宫癌预防和查策略提供信息.
主要方法:
- 一项基于国家实验室的回顾性研究分析了2016年至2024年的9,096份医疗记录.
- 对6,005名患者进行了HPVDNA和细胞检测.
- 评估了HPV基因型分布,时间趋势和地理差异.
主要成果:
- HPV阳性率为13. 84%,其中HPV-16 (25. 11%) 和HPV-18 (7. 55%) 是显著的,与其他高风险菌株 (67. 34%) 一起.
- 在30-39岁的人群中,HPV阳性率达到峰值,从2016年的5.62%增加到2024年的13.33%.
- 吉达 (33.7%) 和利雅得 (32.25%) 呈现出最高的阳性;13.41%的细胞检测样本有癌前病变,0.64%有癌性病变.
结论:
- 在沙特阿拉伯,HPV患病率存在显著的年龄和区域差异,非16/18基因型占主导地位.
- 广泛的疫苗接种,持续的基因型监测和量身定制的区域查对于降低子宫癌负担至关重要.
- 同时测试HPVDNA和细胞检测是很重要的,因为19. 37%的HPV阳性病例的细胞检测正常.
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