膀出口阻塞对男性膀收缩性与年龄相关的变化的影响
Jin Bong Choi1, Kang Jun Cho1, Joon Chul Kim1
1Department of Urology, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
目的:
由于衰老引起的膀胱收缩力改变是老年男性下尿路症状(LUTS)的重要病因之一。本研究旨在观察临床常用治疗LUTS药物对老年男性患者膀胱收缩力随年龄增长所产生变化的影响。
材料与方法:
年龄超过40岁的男性患者,自2012年1月至2024年12月因下尿路症状(LUTS)接受尿动力学检查者被纳入研究。采用膀胱出口梗阻(BOO)指数来区分存在或不存在BOO的男性患者。通过膀胱收缩力指数分析各组中膀胱收缩力随年龄的变化情况。采用皮尔逊相关系数(r) 用于计算年龄与各变量之间线性关系的强度。
结果:
共有449名因下尿路症状接受尿动力学检查的男性患者符合本研究纳入条件(其中311例属于膀胱出口梗阻组,138例属于非膀胱出口梗阻组)。在两组中,年龄与最大尿流率均呈负相关。年龄与膀胱收缩力在非膀胱出口梗阻组中存在显著相关性(p=0.021),但在膀胱出口梗阻组中无显著相关性(p=0.057)。
结论:
本研究发现,膀胱出口梗阻(BOO)可能在评估老年膀胱收缩力时充当混杂因素。在排除BOO的影响后,膀胱收缩力随年龄增长而显著下降。因此,在治疗男性下尿路症状(LUTS)时,由衰老引起的膀胱收缩力变化因BOO的存在与否而异。
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