亚贝马西克利布诱导的间歇性肺病的发生率:日本单中心回顾性研究
Takeshi Hashimoto1, Haruna Nakamura1,2, Yoko Sakoda1
1Department of Breast Surgery, Kakogawa Central City Hospital, Kakogawa, Japan.
The Kobe journal of medical sciences
|September 2, 2025
概括
在乳腺癌患者中,从abemaciclib治疗中发生间歇性肺病 (ILD) 的发生率为20. 4%. 肺转移被确定为发生这种不良事件的重要危险因素.
科学领域:
- 癌症学
- 肺病学
- 药物监督管理
背景情况:
- 阿贝马西克是治疗ER阳性,HER2阴性乳腺癌的CDK4/ 6抑制剂.
- 间歇性肺病 (ILD) 是abemaciclib已知的不良反应之一,亚洲人群的发病率较高.
- 关于阿贝马西利布诱导ILD的发病率和风险因素的数据有限.
研究的目的:
- 在乳腺癌患者中确定abemaciclib诱导的ILD发病率.
- 确定与abemaciclib诱导的ILD发展相关的风险因素.
主要方法:
- 在接受abemaciclib治疗的ER阳性,HER2阴性不可手术或转移性乳腺癌患者的回顾性分析.
- 呼吸系统医学专家对计算机断层扫描进行评估以诊断ILD.
- 单变量分析以确定与ILD发展相关的因素.
主要成果:
- 这项研究分析了49名患者,平均随访时间为27个月.
- 在10名患者 (20. 4%) 诊断出阿贝马西基布诱导的ILD,其中7例是在治疗开始后6个月内发生的.
- 肺转移被确定为ILD的一个显著风险因素 (OR=5. 00,p=0. 032).
结论:
- 亚贝马西利布诱导的ILD发病率 (20.4%) 比之前报告的更高.
- 在接受abemaciclib治疗乳腺癌的患者中,建议提高ILD的警.
- 肺转移是abemaciclib诱导的ILD的一个关键风险因素.
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