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在认知正常的ApoE ε4载体中,补偿性视网膜血流增强
Jing Zhang1, Qiuchen Cao2, Weijie Chen2
1Department of Neurology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, 210029, China.
Scientific reports
|September 2, 2025
概括
ApoE ε4 携带者表现出视网膜血液流动的改变,其状血管区域较小,血管密度增加. 这些变化可能是早期阿尔茨海默病风险的信号.
科学领域:
- 眼科 眼科
- 神经科学
- 遗传学
背景情况:
- 无脂蛋白E (ApoE) ε4基因是晚期阿尔茨海默病 (AD) 的重要遗传风险因素.
- 视网膜血管变化可能反映大脑血管健康,并作为AD等神经退行性疾病的潜在生物标志物.
研究的目的:
- 调查认知健康的 ApoE ε4 携带者与非携带者之间的视网膜血管特征差异.
- 探索这些视网膜变化是否可以作为阿尔茨海默病的早期指标.
主要方法:
- 使用扫描源光学连贯断层扫描 (SS-OCTA) 来分析84名健康个体的视网膜血管 (20名ApoE ε4携带者,64名非携带者).
- 量化参数包括体无血管区 (FAZ) 面积,血管周长,无循环度指数 (AI) 和血管密度 (FD).
- 测量了外视网膜和胆道毛细血管的血液流动,以及表面血管复合体 (SVC) 的非透区域.
主要成果:
- 与非载体相比,ApoE ε4载体的FAZ面积显著减少.
- 在 ApoE ε4 载体中观察到深层和表面血管复合体的形血管密度增加.
- 两组之间没有发现AI,FD,血液输液区域或周围血管密度的显著差异.
结论:
- 在ApoE ε4载体中,FAZ面积的减少和体血管密度的增加可能是视网膜血流变化的补偿机制.
- 这些视网膜血管变化可能成为阿尔茨海默病的早期生物标志物.
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