孕期环境酸盐暴露与母亲甲状腺激素水平之间的关联
Lin Tao1,2,3, Shimin Xiong1,2, Lulu Dai1,2,4
1School of Public Health, Zunyi Medical University, Zunyi, 563000, Guizhou Province, China.
Archives of toxicology
|September 2, 2025
概括
孕妇在怀孕期间接触甲酸盐会影响甲状腺激素. 这项研究发现了剂量反应关系和非线性效应,表明PAE会破坏母亲的甲状腺功能,因此需要减少暴露和监测.
科学领域:
- 环境健康
- 内分泌学
- 生殖毒理学
背景情况:
- 酸盐 (PAE) 是已知的内分泌干扰化合物,在怀孕期间对母亲甲状腺激素有争议的影响.
- 了解PAE暴露对母亲甲状腺功能的影响对于母亲和胎儿的健康至关重要.
研究的目的:
- 在孕妇中研究尿路PAE代谢物与血清甲状腺激素之间的关系.
- 阐明PAE暴露与母亲甲状腺激素水平之间的剂量反应和非线性关联.
主要方法:
- 使用线性混合效应模型 (LMM) 来评估PAE代谢物与甲状腺激素之间的相关性.
- 使用限制立方线 (RCS) 分析进行剂量反应评估.
- 应用贝叶斯核机器回归 (BKMR) 来识别整体和非线性效应.
主要成果:
- 一些PAE代谢物 (MMP,MEHP,MECPP,MIBP,MOP,MBZP) 与总甲状腺素 (TT4),自由三甲状腺素 (FT3) 和自由甲状腺素 (FT4) 有相关性.
- RCS分析证实了剂量反应关系,其中MEHP,MBZP和MIBP是显著的贡献者.
- BKMR显示了PAE暴露与母亲甲状腺激素之间的反向U形,非线性关系.
结论:
- 孕妇在怀孕期间接触甲酸盐会对孕妇的甲状腺激素分泌产生不利影响.
- 这些发现强调了在怀孕期间尽量减少酸盐暴露的重要性.
- 建议在暴露于PAE的孕妇中密切监测甲状腺激素水平.
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