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Updated: Sep 9, 2025

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram
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细胞膜胆固醇由于转运物质寡合化变化而影响着血清素转运物质流出

Deborah Rudin1, Dino Luethi1,2, Marco Niello1,3

  • 1Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Waehringer Strasse 13A, 1090, Vienna, Austria.

Molecular psychiatry
|September 2, 2025
PubMed
概括

降低胆固醇会影响单胺转运体 (MAT) 功能,降低吸收和结合亲和力. 这影响了输送器构造和SERT寡合化,选择性地增加了通过SERT输出的安非他命.

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