在单独的脏患者的上路泌尿瘤中进行激进脏切除与脏节约手术:ROBUUST 2.0注册表的多机构分析
Francesco Ditonno1, Alessandro Veccia1, Gabriele Bignante2
1Department of Urology, Azienda Ospedaliera Universitaria Integrata Verona, University of Verona, Verona, 37126, Italy.
World journal of urology
|September 2, 2025
概括
在单独的脏患者中,对于上路泌尿道癌 (UTUC) 的根性瘤切除术 (RNU) 是罕见的. 结果与节约手术 (KSS) 相似,尽管术后负担较高,但癌症存活率较好.
科学领域:
- 泌尿外科
- 癌症学
- 肝脏病学
背景情况:
- 患有单一脏的患者的上部泌尿道癌 (UTUC) 具有独特的临床挑战.
- 彻底切除术 (RNU) 和节约手术 (KSS) 是治疗选择,对于缺乏对侧的患者,每一种都具有不同的影响.
研究的目的:
- 在UTUC单独的脏患者中比较RNU和KSS的瘤和外科治疗结果.
- 评估UTUC在脏损伤环境中的手术治疗的可行性和有效性.
主要方法:
- 全球多中心注册 (ROBUUST 2. 0) 对UTUC孤独患者的回顾性分析.
- 在RNU和KSS组之间对基线人口统计,疾病特征和外科特征进行比较.
- 卡普兰- 梅尔生存分析 (RFS,MFS,CSS,OS) 对RNU患者进行3年和5年的随访.
主要成果:
- 39名患者接受了RNU (76. 5%) 和12名患者接受了KSS (23. 5%).
- 尽管手术前功能和并发症率相似,但RNU患者的平均停留时间 (LOS) 显著增加.
- 在3年后,RNU患者的生存率为83. 9%,CSS为96. 9%,RFS为71. 8%和MFS为84. 4%,在5年后,这些比例分别为73. 4%,83.1%,59. 9%和78. 5%.
结论:
- 接受RNU或KSS的单独患者面临重大外科手术前的挑战.
- 这项研究显示,单独治疗脏病患者的瘤治疗结果有利,与现有文献相比,尽管存在固有风险,但仍支持手术.
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