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Updated: Sep 9, 2025

Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis
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Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis

Published on: January 26, 2024

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同时激活STING和淋巴毒素β受体诱导B细胞响应在三级淋巴体结构中以增强抗瘤免疫力

Junko Sawada1, Yasuhiro Kikuchi1, Maxwell Duah1

  • 1Cancer and Blood Disorders Institute, Institute for Fundamental Biomedical Research, and Department of Surgery, Johns Hopkins All Children's Hospital, and Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, St. Petersburg, FL, USA.

Nature immunology
|September 2, 2025
PubMed
概括

同时激活STING和淋巴毒素-β受体 (LTβR) 途径会产生三级淋巴体结构 (TLS),增强抗瘤免疫力并改善长期存活. 单独激活STING并没有产生这些治疗效益.

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