一个系统的审查,预测在肝移植期间的再输血后高胆血症的预测因素
Vida Naderi Boldaji1, Ali Reza Safarpour2, Mohammad Ali Sahmeddini3
1Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
BMC anesthesiology
|September 2, 2025
概括
肝移植期间的再输后高血 (PRHK) 是一种严重的并发症. 本次审查确定了对PRHK有助于预测和管理的关键接受者和捐助者因素.
科学领域:
- 移植医学 移植医学
- 麻醉学 麻醉学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 肝移植 (LT) 是对末期肝病的救生程序.
- 高血症 (血清≥5mEq/L) 是LT期间的一个关键并发症,特别是在再输血后.
- 麻醉师的目标是预测和管理高卡利米亚,以减轻风险.
研究的目的:
- 在肝移植中系统地审查与再生输后高血 (PRHK) 相关的接受者和供体特征.
- 确定PRHK的风险因素,以改善患者的治疗结果.
主要方法:
- 在主要数据库 (Web of Science,Scopus,Science Direct,PubMed) 进行了系统的文献搜索.
- 搜索涵盖了1990年1月1日至2023年6月的出版物.
- 包括的研究重点是接受者和捐赠者因素,这些因素有助于在LT期间再输血后导致高卡莱米亚.
主要成果:
- 确定的危险因素包括较高的基线,红血细胞输血参数,某些药物 (血管激素受体阻断剂,二碳酸,甲醇胺),代谢性酸性,低心力输出,毒脉绕道,低尿量,延长麻醉时间,低专蛋白,高排泄物K +,以及捐赠者的特征 (老年人,生活相关,长时间住院).
- 这些因素共同导致PRHK的发生.
结论:
- 本审查整合了在LT期间与PRHK有关的与捐赠者和接受者相关的因素.
- 建议进一步研究PRHK的病理生理机制和诱导因素,特别是在扩展标准供体 (ECD) 肝移植中.
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