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在2型糖尿病中,轻度炎症与远端感觉运动多神经病变之间的关联:横截面研究

Sihua Huang¹, Yan Lan¹, Cheng Zheng¹

¹Department of Endocrinology, Wuming Hospital, affiliated with Guangxi Medical University, Nanning, Guangxi, China.

|September 2, 2025

概括

炎症生物标志物,脂质和功能与糖尿病多神经病有关. 胰岛素样生长因子-1和APOA1/APOB比率是2型糖尿病中对DSPN的保护因素.

科学领域:

内分泌学
神经学
肝脏病学

背景情况:

炎症过程与糖尿病远端感觉运动多神经病变 (DSPN) 的发生有关.
在2型糖尿病 (T2DM) 中了解DSPN的临床特征和相关生物标志物至关重要.

研究的目的:

确定T2DM与DSPN的临床特征.
在患有DSPN的T2DM患者中研究炎症生物标志物,IGF-1和脂质特征.
在T2DM患者和没有DSPN患者中比较功能.

主要方法:

一项横截面研究包括160名T2DM患者和22名健康对照患者.
根据DSPN的严重程度 (不存在,轻度,中度,严重) 患者被分为四组.
评估了临床特征,炎症生物标志物 (INF-γ,IL- 1β,IL- 4,IL- 6),IGF- 1脂质特征 (TC,LDL- C,APOB,APO- A1),以及功能 (Cystatin C).

主要成果:

中度和严重的DSPN与年龄较大和糖尿病持续时间较长有关.
在严重的DSPN患者中观察到INF-γ,IL- 1β,IL- 4和IL- 6的升高水平.
在DSPN患者中观察到较低的IGF- 1水平和变化的脂质样本 (TC,LDL- C,APOB增加;APO- A1/ APOB减少).
在严重的DSPN中,增加的cystatin C水平表明功能受损.
多变量分析确定IL-6,IL-1β,TC,LDL-C,cystatin C,年龄和糖尿病持续时间为DSPN的风险因素,而IGF-1和APOA1/APOB比率是保护性的.

结论:

在T2DM中,严重的DSPN与炎症生物标志物 (INF-γ,IL-1β,IL-4,IL-6) 的增加有关.
年龄,糖尿病持续时间,IL- 6,IL- 1β,TC,LDL- C和囊素的升高与DSPN有积极关联.
在T2DM中,IGF-1和APOA1/APOB比率作为独立的防护因子.
解决炎症生物标志物,脂质和早期功能障碍对于治疗DSPN的T2DM至关重要.

关键词:

远端感觉运动多神经病变炎症生物标志物胰岛素类生长因子-1 脂质美国国家安全局 2 型糖尿病

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