成年人系统性炎症和心血管疾病总指数之间的非线性关联:来自NHANES 2011-2020年的证据
在PubMed上查看摘要
概括
此摘要是机器生成的。通过系统性炎症总指数 (AISI) 衡量系统性炎症,与心血管疾病 (CVD) 患病率有很强的联系. 较高的AISI水平表明美国成年人患心血管疾病的风险增加.
科学领域
- 心血管医学
- 炎症研究
- 公共卫生分析
背景情况
- 炎症与心血管疾病 (CVD) 之间的联系已确立,但系统性炎症总指数 (AISI) 的作用仍未得到充分研究.
- 使用中性细胞,单细胞和血小板数量相对于淋巴细胞数量来计算AISI.
- 研究AISI为心血管疾病机制提供了新的见解.
研究的目的
- 检查美国成年人系统性炎症 (AISI) 和心血管疾病 (CVD) 患病率之间的联系.
- 确定AISI和CVD之间的潜在门和非线性关系.
- 评估这种关联在不同的人口和临床小组中的一致性.
主要方法
- 利用了2011-2020年国家健康和营养检查调查 (NHANES) 数据库中的23472名成年人的数据.
- 使用加权的通用线性模型,子组分析和值效应分析来评估AISI-CVD关系.
- 使用平滑曲线分析可视化非线性关联.
主要成果
- 随着AISI水平的提高,心血管疾病的患病率显著增加 (P < 0. 001).
- 与最低四分位数相比,AISI最高四分位数的人患心血管疾病的几率增加了1. 27倍.
- 观察到非线性关系,临界转折点为AISI=467;在此以上,AISI每增加100个单位与心脏病发病率上升3%相关 (OR=1. 03).
- 不管年龄,种族,吸烟,高脂血症,高血压和糖尿病,这种关联在各个小组中保持一致.
结论
- 这项研究提供了强有力的证据,证明AISI与心脏病发病率之间存在显著的正相关性.
- 这些发现强调了AISI作为心血管风险的生物标志物的潜力.
- 建议进行进一步的前性研究,以充分阐明AISI在心血管疾病的病因和进展中的作用.
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