从指导方针到实践:在心血管风险非常高的患者中达到LDL-C - 分析EDHIPO MARCA注册表
在PubMed上查看摘要
概括
此摘要是机器生成的。在高危患者中,低密度脂蛋白胆固醇 (LDL- C) 目标的实现仍然不理想,尽管接受了降脂疗法. 在冠状动脉疾病患者中,频繁的随访和组合治疗是改善脂质控制的关键.
科学领域
- 心脏病学
- 公共卫生
背景情况
- 心血管疾病是全球主要的死亡原因,而脂质障碍症对其进展有重大影响.
- 尽管降脂疗法 (LLT) 取得了进展,但达到目标低密度脂蛋白胆固醇 (LDL- C) 水平仍然是许多患者面临的挑战.
研究的目的
- 评估哥伦比亚患者因冠状动脉疾病 (CAD) 导致心血管风险非常高的LDL- C目标的实现.
- 评估目标的实现与ESC/EAS指南的更新保持一致.
主要方法
- 一项回顾性多中心研究 (EDHIPO MARCA) 涉及哥伦比亚11个机构的1788名CAD患者.
- 根据ESC/EAS指南的更新,对三个时期 (2011-2012,2016-2017,2021-2022) 的LDL-C目标的实现进行了分析.
- 数据包括冠状动脉图报告和医疗记录,LDL- C目标为< 70 mg/ dL和< 55 mg/ dL.
主要成果
- 在随访期间,总体LDL- C目标达到36. 6%.
- 根据指南期间,目标实现率有所不同:12.1% (2011),42.3% (2016) 和36.2% (2019).
- 随访频率增加与更高的目标实现相关 (32. 9% 随访1次与 44. 0% 随访4次).
结论
- 尽管在非常高的CVR患者中广泛使用LLT,但LDL- C目标的实现仍然不足.
- 加强脂质控制可能需要更频繁的患者随访和除了他类药物之外更广泛的组合治疗.
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