Search

Search

这页已由机器翻译。其他页面可能仍然显示为英文。 View in English

首页
...
研究领域生物医学和临床科学瘤学和致癌症预测和预后标志物
SLC16A3作为一种免疫抑制的库普费尔细胞标志物预测HBV阳性肝细胞癌的预后不佳

SLC16A3作为一种免疫抑制的库普费尔细胞标志物预测HBV阳性肝细胞癌的预后不佳

Jingcheng Zhang ^1,2, Yuyan Pan ^2,3, Zhengqi Zhao ^1,2, Bochen Chen ^2,3, Wei Fan ^1,2, Sicheng Zhao ^1,2, Yuanlin Lv ⁴, Tao Jiang ^5,6

Jingcheng Zhang ^1,2, Yuyan Pan ^2,3, Zhengqi Zhao ^1,2

¹School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
²Key Laboratory of Blood-Stasis-Toxin Syndrome of Zhejiang Province, Hangzhou, China.
³The First Affiliated Hospital of Zhejiang, Chinese Medical University, Hangzhou, China.
⁴School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China. lvyuanlin99@163.com.
⁵School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China. jttcm@zcmu.edu.cn.
⁶Key Laboratory of Blood-Stasis-Toxin Syndrome of Zhejiang Province, Hangzhou, China. jttcm@zcmu.edu.cn.

⁰School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.

Journal of Translational Medicine +

|

2025年九月2日

相关实验视频

These videos have been matched automatically. Contact us if they are not relevant.

Mast Cells in the Microenvironment of Hepatocellular Carcinoma Confer Favorable Prognosis: A Retrospective Study using QuPath Image Analysis Software

Mast Cells in the Microenvironment of Hepatocellular Carcinoma Confer Favorable Prognosis: A Retrospective Study using QuPath Image Analysis Software

Published on: April 12, 2024

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Published on: September 25, 2019

Study of Viral Vectors in a Three-dimensional Liver Model Repopulated with the Human Hepatocellular Carcinoma Cell Line HepG2

Study of Viral Vectors in a Three-dimensional Liver Model Repopulated with the Human Hepatocellular Carcinoma Cell Line HepG2

Published on: October 24, 2016

See all related videos

在PubMed上查看摘要

概括

此摘要是机器生成的。

在乙型肝炎病毒阳性肝细胞癌 (HCC) 中,溶性载体家族16成员3 (SLC16A3) 的高调,表明预后不佳. SLC16A3 影响瘤免疫微环境,并直接影响HCC细胞增殖.

科学领域

癌症学
病毒学
免疫学

背景情况

肝细胞癌 (HCC) 是全球主要的健康威胁,而乙型肝炎病毒 (HBV) 感染是主要的风险因素.
识别分子点对于治疗HBV阳性HCC至关重要.

研究的目的

研究SLC16A3在肝癌中的作用及其有关HBV状态的微环境.
在HBV阳性HCC患者中确定SLC16A3的预后意义.

主要方法

单细胞和转录组测序分析.
临床HCC队列的免疫组织化学染色.
在不同HBV状态的HCC细胞系上进行体外实验.

主要成果

与正常组织和HBV阴性HCC相比,SLC16A3表达显著上调.
上调的SLC16A3与预后不佳相关,并与库普弗细胞分化和抑制性免疫微环境有关.
SLC16A3直接促进HBV阳性HCC细胞系的增殖.

结论

SLC16A3 作为 HBV 阳性 HCC 的显著预后标志物.
SLC16A3与异常的Kupffer细胞代谢和免疫调节有关,直接影响HBV阳性HCC的进展.

关键词:

没有HBV 肝细胞癌其他类型癌症免疫力

相关实验视频

这些视频已自动匹配 Contact us 如果它们不相关

Mast Cells in the Microenvironment of Hepatocellular Carcinoma Confer Favorable Prognosis: A Retrospective Study using QuPath Image Analysis Software

Mast Cells in the Microenvironment of Hepatocellular Carcinoma Confer Favorable Prognosis: A Retrospective Study using QuPath Image Analysis Software

Published on: April 12, 2024

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Published on: September 25, 2019

Study of Viral Vectors in a Three-dimensional Liver Model Repopulated with the Human Hepatocellular Carcinoma Cell Line HepG2

Study of Viral Vectors in a Three-dimensional Liver Model Repopulated with the Human Hepatocellular Carcinoma Cell Line HepG2

Published on: October 24, 2016

See all related videos

Share

X
Facebook
LinkedIn
YouTube

ABOUT JoVE

Overview
Leadership
Blog
JoVE Help Center

AUTHORS

Publishing Process
Editorial Board
Scope & Policies
Peer Review
FAQ
Submit

LIBRARIANS

Testimonials
Subscriptions
Access
Resources
Library Advisory Board
FAQ

RESEARCH

JoVE Journal
Methods Collections
JoVE Encyclopedia of Experiments
Archive

EDUCATION

JoVE Core
JoVE Business
JoVE Science Education
JoVE Lab Manual
Faculty Resource Center
Faculty Site

Terms & Conditions of Use
Privacy Policy
Policies