消化神经内分泌瘤内镜切除后的并发症和复发风险:一个回顾性研究
Yuan Si1, HongZhi Wu2, Chao Wang1
1Endoscopic Center, XingTai People's Hospital, Xingtai City, 054001, China.
Orphanet journal of rare diseases
|September 2, 2025
概括
消化神经内分泌瘤的内切除是安全的,并发症率很低. 高度瘤和更大的瘤可能会增加复发风险,因此需要仔细的随访.
科学领域:
- 胃肠病学
- 外科瘤学
- 透视外科手术
背景情况:
- 消化系统神经内分泌瘤 (NETs) 存在手术前后并发症和复发的风险.
- 对这些瘤进行内镜切除的长期结果和安全性的评估至关重要.
研究的目的:
- 对消化系统NET进行内镜下粘膜解剖和粘膜切除的长期安全性和有效性进行评估.
- 确定内镜切除后复发和并发症相关的因素.
主要方法:
- 针对胃,十二指肠或直肠NET进行内切除的100名患者进行了回顾性队列研究.
- 对复发和并发症的随访数据进行了分析.
- 治疗切除标准遵循欧洲胃肠内镜学会 (ESGE) 的指导方针.
- 通过内镜超声波 (EUS) 和/或活检进行术前确认.
主要成果:
- 平均瘤大小为6-11. 3毫米;平均手术时间为6-13分钟.
- 并发症包括出血 (6%),穿孔 (4%),恶心 (16%),吐 (5%).
- 局部复发发生在3% (胃/十二指肠病变),远端转移发生在2%. 没有人死亡.
- 2级,瘤大小≥9. 5毫米,胃/直肠病变与转移有关.
结论:
- 对于消化系统的NET,特别是胃和直肠的NET,内镜切除似乎是安全的.
- 高度瘤和较大的病变大小与复发和转移风险的增加有关.
- 对于通过内镜治疗的消化 NET 进行仔细的患者选择和随访至关重要.
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