基因检测网:解开全球病原体的基因组难题
Shivendra Dubey1, Sakshi Dubey2, Kapil Raghuwanshi3
1Department of Artificial Intelligence & Machine Learning, Manipal University Jaipur, Jaipur, India. shivendra.dubey@jaipur.manipal.edu.
Tropical diseases, travel medicine and vaccines
|September 2, 2025
概括
这项研究介绍了GenoDense-Net,这是一种用于COVID-19基因组序列分析的深度学习模型,其准确度达到了99.18%. 像COVID-19这样的传染病的早期诊断对于公共健康至关重要.
科学领域:
- 生物信息学
- 计算生物学
- 医学中的机器学习
背景情况:
- 诸如COVID-19之类的传染性呼吸道疾病对人类健康构成重大威胁.
- 早期发现和诊断对于控制传染病的传播至关重要.
- 基因组测序为了解和识别感染病原体提供了有价值的数据.
研究的目的:
- 开发和评估用于分类COVID-19基因组序列的深度学习技术.
- 根据已有的深度学习模型评估拟议的GenoDense-Net架构的性能.
- 展示机器学习在分析传染病基因组数据中的实用性.
主要方法:
- 使用DenseNet-16框架进行基因组序列分析.
- 员工转移学习以适应预先训练的神经网络与COVID-19数据集.
- 应用NearKbest插入数据预处理和Adam Optimizer进行模型优化.
- 将拟议的方法与ResNet-50,VGG-19,AlexNet和VGG-16模型进行比较.
主要成果:
- 在COVID-19基因组序列的分类准确率达到了99.18%.
- 与其他深度学习架构相比,GenoDense-Net模型表现出卓越的性能.
- 支持GPU的部署大大减少了模型训练时间.
结论:
- 拟议的GenoDense-Net深度学习方法对于分类传染病基因组序列,特别是COVID-19有效.
- 这项研究强调了人工智能在加速基因组数据分析以快速识别疾病方面的潜力.
- 未来的工作包括临床验证和扩展数据集以进行进一步调查.
相关概念视频
Genomics
37.4K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
37.4K
Modern Molecular Taxonomy
136
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
136
Genomic DNA in Eukaryotes
47.6K
Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
47.6K
Horizontal Gene Transfer
125
Horizontal gene transfer (HGT) is a process where genetic material moves between organisms within the same generation, unlike vertical gene transfer, which occurs from parent to offspring. HGT plays a crucial role in microbial evolution, adaptation, and survival, particularly in shared environments like the human gut.Mobile genetic elements such as plasmids, prophages, integrons, insertion sequences, and transposons facilitate this process. HGT occurs through three primary mechanisms:...
125
Genomic DNA in Prokaryotes
44.5K
The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...
Genomic Diversity in Bacteria
Although bacterial genomes are much...
44.5K
Genome Size and the Evolution of New Genes
8.3K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
8.3K


