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巨源的VEGF调节巨衰老以抑制辐射诱导的皮肤炎

Rishi Man Chugh¹, Pooja Gupta-Saraf¹, Payel Bhanja¹

¹Department of Radiation Oncology, University of Kansas Medical Center, Kansas City, KS, 66160, USA.

Journal of translational medicine

|September 2, 2025

概括

巨源血管内皮生长因子 (VEGF) 防止衰老并维持功能,改善辐射后的皮肤健康. 向VEGF信号可以减少辐射引起的皮肤损伤并改善患者的治疗结果.

科学领域:

免疫学
细胞生物学
皮肤病学

背景情况:

巨细胞对于组织修复至关重要,但在辐射引起的皮肤炎中可能会受到损害.
研究了来自巨细胞的血管内皮生长因子 (VEGF) 在调节巨细胞衰老和辐射皮肤损伤方面的作用.

研究的目的:

分析巨衍生的VEGF在巨衰老的调节中的作用.
确定VEGF对辐射引起的皮肤损伤的影响.

主要方法:

使用的无VEGF和野生类型的骨髓衍生巨细胞 (BMM) 暴露于压力.
通过SA-β-Gal染色和基因表达来评估衰老.
对没有巨细胞VEGF的辐射小鼠进行了体内研究.

主要成果:

没有VEGF的巨细胞表现出增长的衰老和功能减弱 (细胞,迁移).
野生型巨细胞的VEGF受体抑制增加了衰老标志物.
缺乏巨细胞衍生的VEGF的小鼠表现出更严重的辐射皮肤炎.

结论:

缺少来自巨细胞的VEGF会损害巨细胞的功能,并使辐射性皮肤炎恶化.
向VEGF信号是一种潜在的治疗策略,用于辐射皮肤毒性.

关键词:

细胞循环停止大细胞衰老细胞发生辐射引起的皮肤炎血管内皮生长因子

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