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增长激素对中国过渡性增长激素缺乏症患者的骨密度和身体组成的影响
Qingbo Xu1,2, Yu Yang1,2, Jiangwei Ke2,3
1Department of Endocrinology, Jiangxi Provincial Children's Hospital, Jiangxi, China.
Medicine
|September 3, 2025
概括
在过渡性生长激素缺乏症 (TGHD) 的青少年中,持续的复合人体生长激素 (rhGH) 治疗显著改善了骨矿物质密度 (BMD) 和身体组成. 停止治疗导致骨质量下降和脂质异常,强调需要持续的GH治疗.
科学领域:
- 内分泌学
- 儿童内分泌学
- 代谢性骨疾病
背景情况:
- 过渡性生长激素缺乏症 (TGHD) 在青少年中具有独特的挑战,影响骨矿物质密度 (BMD) 和身体组成.
- 需要进一步阐明重组人体生长激素 (rhGH) 在关键阶段管理TGHD的作用.
- 了解rhGH对肌肉骨健康和代谢参数的长期影响对于优化治疗策略至关重要.
研究的目的:
- 评估持续的rhGH治疗对中国青少年TGHD的骨质量和身体构成的影响.
- 评估rhGH治疗对TGHD患者的生化特征,握力和心脏功能的影响.
- 在TGHD治疗中确定持续GH替代的必要性,直到达到峰值骨质量.
主要方法:
- 一项前性队列研究,涉及37名TGHD患者 (15-18岁) 和7名健康对照.
- 患者接受了为期3个月的rhGH洗,随后分为rhGH继续治疗 (n=4) 和非治疗 (n=5) 组.
- 评估包括双能量X射线吸收测量 (DXA) 测定骨质量和身体组成,生物化学分析,握力和心脏超声波.
主要成果:
- 与基线和非治疗组相比,接受 rhGH 治疗的TGHD 患者的腰部骨质量和握力显著改善.
- 未经治疗的TGHD患者体验到骨质量下降和握力恶化,以及血脂不良 (高甘油和LDL- C) 的发展.
- 在两组中都没有观察到生长速度,IGF-1或心脏功能的显著变化.
结论:
- 在过渡期继续使用rhGH治疗对于改善骨质结构,保持良好的身体组成以及减轻TGHD患者的代谢风险至关重要.
- 停用rhGH会加剧肌肉骨缺陷和脂质异常,强调需要持续补充GH,直到骨质量达到峰值.
- 除了线性增长优化之外,rhGH在TGHD的综合管理中起着至关重要的作用.
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