维生素D与成年人身高之间的因果关系:双向孟德尔随机化研究
Lianhui Chen1,2, Min Wu1, Zhenzhong Zeng1
1Department of Pediatrics, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
Medicine
|September 3, 2025
概括
较高的维生素D水平会导致成人身高增加,但身高不会影响维生素D.这项遗传研究表明,维生素D在骨生长中起到适度的作用,尽管补充剂可能不会显著增加足够水平的人的身高.
科学领域:
- 遗传学
- 内分泌学
- 人类生物学
背景情况:
- 维生素D对骨健康至关重要,但其对成年人身高的直接因果影响尚未完全理解.
- 观察性研究和随机对照试验在确定因果关系方面存在局限性.
- 孟德尔随机化 (MR) 提供了一种强大的方法来研究使用遗传变异的双向因果关系.
研究的目的:
- 探索循环维生素D水平与成年人身高之间的双向因果关系.
- 利用全基因组关联研究的大规模数据进行可靠的遗传分析.
- 要确定维生素D是否会影响成人的身高,或者身高是否会影响维生素D水平.
主要方法:
- 进行了双向的双样本孟德尔随机分析.
- 使用了维生素D (Pan-UKB,n=383,324) 和身高 (FinnGen,n=364,629) 的全基因组关联研究数据.
- 使用逆方差加权 (IVW),MR-Egger和加权中位数方法,并对变性和异质性进行敏感性分析.
主要成果:
- 基因预测较高的维生素D度与成人身高的增加有关 (P=1.53×10−5).
- 维生素D的每一个标准偏差都相当于身高的0. 046标准偏差.
- 没有发现成人身高对维生素D水平有显著的因果关系 (P=0. 343).
结论:
- 这项研究提供了强有力的遗传证据,
- 没有发现反向因果关系 (高度影响维生素D).
- 虽然维生素D对骨发育很重要,但在维生素D水平足够的个体中,补充剂可能不会显著增加身高.
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